Fucose-binding lectin from Burkholderia ambifaria
نویسندگان
چکیده
From CERMAV-CNRS (affiliated to Université Joseph Fourier and ICMG, 38041 Grenoble, France, Albert-Ludwigs-University Freiburg, Institute of Biology II and BIOSS Centre for Biological Signalling Studies, 79104 Freiburg, Germany, # Institut Curie, Centre de Recherche, Traffic, Signaling and Delivery group, CNRS UMR 144, 75248 Paris, France, Inserm, U892, University of Nantes, IRT UN, 44007 Nantes, France, Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden. Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA ¶ Central European Institute of Technology, Masaryk University, 62500 Brno, Czech Republic
منابع مشابه
Molecular Simulations of Carbohydrates with a Fucose-Binding Burkholderia ambifaria Lectin Suggest Modulation by Surface Residues Outside the Fucose-Binding Pocket
Burkholderia ambifaria is an opportunistic respiratory pathogen belonging to the Burkholderia cepacia complex, a collection of species responsible for the rapidly fatal cepacia syndrome in cystic fibrosis patients. A fucose-binding lectin identified in the B. ambifaria genome, BambL, is able to adhere to lung tissue, and may play a role in respiratory infection. X-ray crystallography has reveal...
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Pseudomonas aeruginosa (PA) and Burkholderia ambifaria (BA) are two opportunistic Gram negative bacteria and major infectious agents involved in lung infection of cystic fibrosis patients. Both bacteria can develop resistance to conventional antibiotherapies. An alternative strategy consists of targeting virulence factors in particular lectins with high affinity ligands such as multivalent glyc...
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Anti-adhesive glycoclusters offer potential as therapeutic alternatives to classical antibiotics in treating infections. Pillar[5]arenes functionalised with either five galactose or five fucose residues were readily prepared using CuAAC reactions and evaluated for their binding to three therapeutically relevant bacterial lectins: LecA and Lec B from Pseudomonas aeuruginosa and BambL from Burkho...
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Five fucosylated glycoclusters exhibiting 4, 6 or 8 residues were synthesised with two different spatial environments based on mannose-centered and branched-phosphodiester scaffolds. Their synthesis was performed in solution using phosphoramidite chemistry to generate phosphodiester linkages, combined with Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC). The multivalent ligands were evaluate...
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Bacteriocins of the LlpA family have previously been characterized in the γ-proteobacteria Pseudomonas and Xanthomonas. These proteins are composed of two MMBL (monocot mannose-binding lectin) domains, a module predominantly and abundantly found in lectins from monocot plants. Genes encoding four different types of LlpA-like proteins were identified in genomes from strains belonging to the Burk...
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